The Duo Epinephrine Delivery System enables teens with severe allergies to manage their epinephrine autonomously while providing peace of mind to their parents and caregivers. The system combines a novel needle-free epinephrine nasal spray and familiar epinephrine auto-injector into a single compact Bluetooth-enabled carrying case, along with a companion mobile app. When the case is opened, voice instructions guide the user through administering the medication, and caregivers receive an alert through the mobile app once the epinephrine has been administered.